Nr2c2 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comNr2c2 Polyclonal Antibody for Mouse(Mus musculus)

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Nr2c2 (Gene name),

Nuclear receptor subfamily 2 group C member 2 (Protein name ), NR2C2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Nr2c2(Mtr2r1;Tak1;Tr4);

Protein name:

Nuclear receptor subfamily 2 group C member 2;

Alternative:

Orphan nuclear receptor TR4;Orphan nuclear receptor TAK1;Testicular receptor 4;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity (By similarity). Interacts with PCAF; the interaction preferentially occurs on the nonphosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity.

Function:

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation (By similarity). Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

596

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

596:

RLMSSNITEE | LFFTGLIGNV | SIDSIIPYIL | KMETAEYNGQ | ITGASL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00104

SMR:

P49117

UniGene:

Mm.442385

String:

P49117

KEGG:

mmu:22026

Uniprot:

P49117

FOR

ELISA Kit for Mouse Nuclear receptor subfamily 2 group C member 2

Cat.:

E10644m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Nuclear receptor subfamily 2 group C member 2

Cat.:

E10644r

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Nuclear receptor subfamily 2 group C member 2

Cat.:

E10644h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Nuclear receptor subfamily 2 group C member 2

Cat.:

U10644h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Nuclear receptor subfamily 2 group C member 2

Cat.:

U10644r

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Nuclear receptor subfamily 2 group C member 2

Cat.:

U10644m

Price:

Please sign in first.

MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Nuclear receptor subfamily 2 group C member 2

Cat.:

P10644Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Nuclear receptor subfamily 2 group C member 2

Monoclonal Antibody for Mouse Nuclear receptor subfamily 2 group C member 2

Protein for Mouse Nuclear receptor subfamily 2 group C member 2

Cat.:

R10644h

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis."
Hirose T. , O'Brien D.A. , Jetten A.M.
Gene163:239-242(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: CD-1.
2.

"Molecular cloning of a novel member of the nuclear receptor superfamily related to the orphan receptor, TR2."
Law S.W. , Conneely O.M. , O'Malley B.W.
Gene Expr.4:77-84(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

Young W.J. , Smith S. , Chang C.
Submitted (1996-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6J.
tissue: Testis.
4.

"Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor."
Lee Y.F. , Young W.J. , Lin W.J. , Shyr C.R. , Chang C.
J. Biol. Chem.274:16198-16205(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer."
Tanabe O. , Katsuoka F. , Campbell A.D. , Song W. , Yamamoto M. , Tanimoto K. , Engel J.D.
EMBO J.21:3434-3442(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY AS A COMPONENT OF THE DRED COMPLEX;FUNCTION;SUBCELLULAR LOCATION;HETERODIMERIZATION;DEVELOPMENTAL STAGE
6.

"Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis."
Mu X. , Lee Y.F. , Liu N.C. , Chen Y.T. , Kim E. , Shyr C.R. , Chang C.
Mol. Cell. Biol.24:5887-5899(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;FUNCTION
7.

"Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation."
Huq M.D. , Gupta P. , Tsai N.P. , Wei L.N.
Mol. Cell. Proteomics5:2072-2082(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-19; SER-55 AND SER-68;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH NRIP1 AND PCAF;MUTAGENESIS OF SER-19; SER-55 AND SER-68
8.

"Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor."
Chen Y.T. , Collins L.L. , Uno H. , Chou S.M. , Meshul C.K. , Chang S.S. , Chang C.
Brain Res.1168:72-82(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;FUNCTION
9.

"The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription."
Tanabe O. , Shen Y. , Liu Q. , Campbell A.D. , Kuroha T. , Yamamoto M. , Engel J.D.
Genes Dev.21:2832-2844(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HETERODIMERIZATION;FUNCTION
10.

"Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells."
Shyr C.R. , Kang H.Y. , Tsai M.Y. , Liu N.C. , Ku P.Y. , Huang K.E. , Chang C.
Endocrinology150:2454-2462(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;INDUCTION;FUNCTION
11.

"Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia."
Kim Y.S. , Harry G.J. , Kang H.S. , Goulding D. , Wine R.N. , Kissling G.E. , Liao G. , Jetten A.M.
Cerebellum9:310-323(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
12.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-231;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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